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In a very examine in breast cancer cells, The mixture of lapatinib, a twin HER2/neu and EGFR tyrosine kinase inhibitor, with INK128 prevented each HER2 and HER3 phosphorylation induced by INK128 and developed synergistic induction of mobile Loss of life in different HER2-constructive mobile lines proof against trastuzumab and lapatinib. In vivoGala